Pollen exposure at birth and adolescent lung function, and modification by residential greenness

Abstract

Background: Exposure to high levels of pollen in infancy is a risk factor for allergic respiratory diseases in later childhood, but effects on lung function are not fully understood. We aim to examine associations between grass pollen exposure in the first months of life and lung function at 12 and 18 years, and explore potential modification. Methods: Using the Melbourne Atopy Cohort Study, a birth cohort of children with a family history of allergic diseases, we modeled the association between cumulative grass pollen exposure up to 3 months after birth, on FEV1, FVC, and FEV1/FVC ratio at 12 and 18 years. We also assessed modifying effects of residential greenness levels (derived from sate..